Jacksonville Jaguars vs San Francisco 49ers: every meeting, player stats and projections
At a glance
- Last meeting
- JAX 26, SF 21Sep 28, 2025 · Levi's Stadium, Santa Clara
- Record
- Jaguars 1–0 49ers in the one meeting
- Next meeting
- No meeting on the published schedule.
Game by game
| Date | Game | Score | Result | Stage |
|---|---|---|---|---|
| Sep 28, 2025 | Jaguars at 49ers | JAX 26, SF 21 | Jaguars won | 2025 regular season, Week 4 |
Game leaders
Jaguars at 49ers, JAX 26, SF 21 · Sep 28, 2025
Jacksonville Jaguars- Passing
- Trevor Lawrence 21/31, 174 YDS, 1 TD
- Rushing
- Travis Etienne Jr. 19 CAR, 124 YDS, 1 TD
- Receiving
- Brian Thomas Jr. 5 REC, 49 YDS
San Francisco 49ers- Passing
- Brock Purdy 22/38, 309 YDS, 2 TD, 2 INT
- Rushing
- Christian McCaffrey 17 CAR, 49 YDS
- Receiving
- Christian McCaffrey 6 REC, 92 YDS, 1 TD
Scores, schedule and game leaders via ESPN · updated Oct 21, 2026. Each name opens the player’s page.