Indianapolis Colts vs San Francisco 49ers: every meeting, player stats and projections
At a glance
- Last meeting
- SF 48, IND 27Dec 22, 2025 · Lucas Oil Stadium, Indianapolis
- Record
- Colts 0–1 49ers in the one meeting
- Next meeting
- No meeting on the published schedule.
Game by game
| Date | Game | Score | Result | Stage |
|---|---|---|---|---|
| Dec 22, 2025 | 49ers at Colts | SF 48, IND 27 | 49ers won | 2025 regular season, Week 16 |
Game leaders
49ers at Colts, SF 48, IND 27 · Dec 22, 2025
San Francisco 49ers- Passing
- Brock Purdy 25/34, 295 YDS, 5 TD, 1 INT
- Rushing
- Christian McCaffrey 21 CAR, 117 YDS
- Receiving
- George Kittle 7 REC, 115 YDS, 1 TD
Indianapolis Colts- Passing
- Philip Rivers 23/35, 277 YDS, 2 TD, 1 INT
- Rushing
- Jonathan Taylor 16 CAR, 46 YDS, 1 TD
- Receiving
- Alec Pierce 4 REC, 86 YDS, 2 TD
Scores, schedule and game leaders via ESPN · updated Oct 21, 2026. Each name opens the player’s page.