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Buffalo Bills vs San Francisco 49ers Match Player Stats & Head-to-Head History

NFL · 7 meetings since 1999 in StatIQ's data

Today’s NFL games

At a glance

Last meeting
SF 10, BUF 35Dec 1, 2024
Record
Bills 4–3 49ers in the last 7 meetings
Average score
Bills 23.0, 49ers 21.0 on average in the last 7 meetings
Next meeting
No meeting on the published schedule.

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49ers 10 at Bills 35, Dec 1, 2024: player stats

SFAway10

SF passing
PassingCmpAttYdsTDINTSk
Brock PurdyQB111894002
Team111894002
SF rushing
RushingCarYdsTD
Jordan MasonRB13780
Christian McCaffreyRB7530
Isaac GuerendoRB4191
Brock PurdyQB240
Kyle JuszczykRB1-10
Team271531
SF receiving
ReceivingRecTgtYdsTD
Jauan JenningsWR35560
Deebo Samuel Sr.WR45200
Christian McCaffreyRB23140
George KittleTE1270
Ricky PearsallWR0100
Isaac GuerendoRB11-30
Team1117940

BUFHome35

BUF passing
PassingCmpAttYdsTDINTSk
Josh AllenQB1317148200
Mitchell TrubiskyQB114000
Team1418152200
BUF rushing
RushingCarYdsTD
James CookRB141071
Ray DavisRB11631
Ty JohnsonRB5280
Josh AllenQB3181
Curtis SamuelWR170
Mitchell TrubiskyQB4-30
Team382203
BUF receiving
ReceivingRecTgtYdsTD
Dawson KnoxTE22560
Khalil ShakirWR47300
Amari CooperWR33191
Quintin MorrisTE11140
James CookRB11130
Ty JohnsonRB1190
Mack HollinsWR1171
Ray DavisRB1140
Zach DavidsonTE0100
Team14181522

Passing, rushing and receiving by player, from every play of the game; two-point tries are not counted, as in every Explorer answer.

Team passing yards are the sum of the passers’ yards (sacks are not taken off). Defense, kicking and returns are not in StatIQ’s NFL data, so they are not shown.

Source: StatIQ game data

Game by game

Buffalo Bills vs San Francisco 49ers, game by game
DateGameScoreResultStage
Dec 1, 202449ers at BillsSF 10, BUF 35Bills won2024 regular season, Week 13
Dec 7, 2020Bills at 49ersBUF 34, SF 24Bills won2020 regular season, Week 13
Oct 16, 201649ers at BillsSF 16, BUF 45Bills won2016 regular season, Week 6
Oct 7, 2012Bills at 49ersBUF 3, SF 4549ers won2012 regular season, Week 5
Nov 30, 200849ers at BillsSF 10, BUF 349ers won2008 regular season, Week 13
Dec 26, 2004Bills at 49ersBUF 41, SF 7Bills won2004 regular season, Week 16
Dec 2, 2001Bills at 49ersBUF 0, SF 3549ers won2001 regular season, Week 12

Scores from StatIQ's game data, schedule and game leaders via ESPN · updated Nov 6, 2026. Each name opens the player’s page.

Depth charts, injuries and props